CUSIP No. 670704 10 5                                        Page 1 of 10 Pages


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             ---------------------

                                  SCHEDULE 13G
                                 (Rule 13d-102)

            INFORMATION TO BE INCLUDED IN STATEMENTS FILES PURSUANT
           TO RULES 13d-1(b),(c) AND (d) AND AMENDMENTS THERETO FILED
                           PURSUANT TO RULE 13d-2(b)
                               (Amendment No. )[1]

                                 NuVasive, Inc.
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                                (Name of Issuer)

                         Common Stock, $.001 par value
-------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                  670704 10 5
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                                   May 12, 2004
-------------------------------------------------------------------------------
             Date of Event Which Requires Filing of this Statement

Check the appropriate box to designate the rule pursuant to which this Schedule
is Filed:

         [   ] Rule 13d-1(b)
         [   ] Rule 13d-1(c)
         [X]   Rule 13d-1(d)



-----------------------

         [1]The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page. The information required on
the remainder of this cover page shall not be deemed to be "filed" for the
purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise
subject to the liabilities of that section of the Act but shall be subject to
all other provisions of the Act.


CUSIP No. 670704 10 5 Page 2 of 10 Pages ------------------------------------------------------------------------------- 1) Name of Reporting Person Domain Partners I.R.S. Identification IV, L.P. No. of Above Person (Entities Only) ------------------------------------------------------------------------------- 2) Check the Appropriate Box (a) [X] if a Member of a Group (b) [ ] ------------------------------------------------------------------------------- 3) SEC Use Only ------------------------------------------------------------------------------- 4) Citizenship or Place Delaware of Organization ------------------------------------------------------------------------------- Number of 5) Sole Voting 1,752,455 shares Shares Beneficially Power of Common Stock Owned by Each Reporting Person With ------------------------------------------------------ 6) Shared Voting Power -0- ------------------------------------------------------ 7) Sole Disposi- 1,752,455 shares tive Power of Common Stock ------------------------------------------------------ 8) Shared Dis- positive Power -0- ------------------------------------------------------ 9) Aggregate Amount Beneficially 1,752,455 shares Owned by Each Reporting person of Common Stock ------------------------------------------------------------------------------- 10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares ------------------------------------------------------------------------------- 11) Percent of Class Represented by 7.3% Amount in Row (9) ------------------------------------------------------------------------------- 12) Type of Reporting Person PN

CUSIP No. 670704 10 5 Page 3 of 10 Pages ------------------------------------------------------------------------------- 1) Name of Reporting Person DP IV Associates, I.R.S. Identification L.P. No. of Above Person (Entities Only) ------------------------------------------------------------------------------- 2) Check the Appropriate Box (a) [X] if a Member of a Group (b) [ ] ------------------------------------------------------------------------------- 3) SEC Use Only ------------------------------------------------------------------------------- 4) Citizenship or Place Delaware of Organization ------------------------------------------------------------------------------- Number of 5) Sole Voting 31,204 shares Shares Beneficially Power of Common Stock Owned by Each Reporting Person With ------------------------------------------------------ 6) Shared Voting Power -0- ------------------------------------------------------ 7) Sole Disposi- 31,204 shares tive Power of Common Stock ------------------------------------------------------ 8) Shared Dis- positive Power -0- ------------------------------------------------------ 9) Aggregate Amount Beneficially 31,204 shares Owned by Each Reporting person of Common Stock ------------------------------------------------------------------------------- 10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares ------------------------------------------------------------------------------- 11) Percent of Class Represented by 0.1% Amount in Row (9) ------------------------------------------------------------------------------- 12) Type of Reporting Person PN

CUSIP No. 670704 10 5 Page 4 of 10 Pages ------------------------------------------------------------------------------- 1) Name of Reporting Person Domain Associates, I.R.S. Identification L.L.C. No. of Above Person (Entities Only) ------------------------------------------------------------------------------- 2) Check the Appropriate Box (a) [X] if a Member of a Group (b) [ ] ------------------------------------------------------------------------------- 3) SEC Use Only ------------------------------------------------------------------------------- 4) Citizenship or Place Delaware of Organization ------------------------------------------------------------------------------- Number of 5) Sole Voting 8,000 shares Shares Beneficially Power of Common Stock Owned by Each Reporting Person With ------------------------------------------------------ 6) Shared Voting Power -0- ------------------------------------------------------ 7) Sole Disposi- 8,000 shares tive Power of Common Stock ------------------------------------------------------ 8) Shared Dis- positive Power -0- ------------------------------------------------------ 9) Aggregate Amount Beneficially 8,000 shares Owned by Each Reporting person of Common Stock ------------------------------------------------------------------------------- 10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares ------------------------------------------------------------------------------- 11) Percent of Class Represented by less than 0.1% Amount in Row (9) ------------------------------------------------------------------------------- 12) Type of Reporting Person OO

CUSIP No. 670704 10 5 Page 5 of 10 Pages Schedule 13G ------------ Item 1(a) - Name of Issuer: NuVasive, Inc. Item 1(b) - Address of Issuer's Principal Executive Offices: 10065 Old Grove Road San Diego, CA 92131 Item 2(a) - Name of Person Filing: This statement is being filed by Domain Partners IV, L.P., a Delaware limited partnership ("Domain IV"), DP IV Associates, L.P., a Delaware limited partnership ("DP IV A"), and Domain Associates, L.L.C., a Delaware limited liability company (collectively, the "Reporting Persons"). Item 2(b) - Address of Principal Business Office: One Palmer Square Princeton, NJ 08542 Item 2(c) - Place of Organization: Domain IV: Delaware DP IV A: Delaware DA: Delaware Item 2(d) - Title of Class of Securities: Common Stock, $.001 par value Item 2(e) - CUSIP Number: 670704 10 5 Item 3 - Statements Filed Pursuant to Rules 13d-1(b) or 13d-2(b): Not applicable.

CUSIP No. 670704 10 5 Page 6 of 10 Pages Item 4 - Ownership. (a) Amount Beneficially Owned: Domain IV: 1,752,455 shares of Common Stock DP IV A: 31,204 shares of Common Stock DA: 8,000 shares of Common Stock (b) Percent of Class: Domain IV: 7.3% DP IV A: 0.1% DA: less than 0.1% (c) Number of shares as to which such person has: (i) sole power to vote or to direct the vote: Domain IV: 1,752,455 shares of Common Stock DP IV A: 31,204 shares of Common Stock DA: 8,000 shares of Common Stock (ii) shared power to vote or to direct the vote: -0- (iii) sole power to dispose or to direct the disposition of: Domain IV: 1,752,455 shares of Common Stock DP IV A: 31,204 shares of Common Stock DA: 8,000 shares of Common Stock (iv) shared power to dispose or to direct the disposition of: -0- Item 5 - Ownership of Five Percent or Less of a Class: Not applicable. Item 6 - Ownership of More than Five Percent on Behalf of Another Person: Not applicable. Item 7 - Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Company: Not applicable.

CUSIP No. 670704 10 5 Page 7 of 10 Pages Item 8 - Identification and Classification of Members of the Group: See Exhibit 2. Item 9 - Notice of Dissolution of Group: Not applicable. Item 10 - Certification: Not applicable.

CUSIP No. 670704 10 5 Page 8 of 10 Pages Signature: After reasonable inquiry and to the best of their knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct. DOMAIN PARTNERS IV, L.P. By: One Palmer Square Associates IV, L.L.C., General Partner By /s/ Kathleen K. Schoemaker --------------------------- Managing Member DP IV ASSOCIATES, L.P. By: One Palmer Square Associates IV, L.L.C., General Partner By /s/ Kathleen K. Schoemaker --------------------------- Managing Member DOMAIN ASSOCIATES, L.L.C. By /s/ Kathleen K. Schoemaker --------------------------- Managing Member Date: January 5, 2005

CUSIP No. 670704 10 5 Page 9 of 10 Pages EXHIBIT 1 AGREEMENT OF DOMAIN PARTNERS IV, L.P., DP IV ASSOCIATES, L.P. AND DOMAIN ASSOCIATES, L.L.C. PURSUANT TO RULE 13d-1(f) ------------------------- The undersigned hereby agree that the Information Statement on Schedule 13G to which this Agreement is annexed as Exhibit 1 is filed on behalf of each of them in accordance with provisions of 13d-1(f) under the Securities Exchange Act of 1934, as amended. DOMAIN PARTNERS IV, L.P. By: One Palmer Square Associates IV, L.L.C., General Partner By /s/ Kathleen K. Schoemaker --------------------------- Managing Member DP IV ASSOCIATES, L.P. By: One Palmer Square Associates IV, L.L.C., General Partner By /s/ Kathleen K. Schoemaker --------------------------- Managing Member DOMAIN ASSOCIATES, L.L.C. By /s/ Kathleen K. Schoemaker --------------------------- Managing Member Date: January 5, 2005

CUSIP No. 670704 10 5 Page 10 of 10 Pages EXHIBIT 2 Identification and Classification of Members of the Group --------------------------------- Domain Partners IV, L.P., DP IV Associates, L.P. and Domain Associates, L.L.C. are filing this statement on Schedule 13G as a group. Domain Partners IV, L.P. is a Delaware limited partnership. Its sole general partner is One Palmer Square Associates IV, L.L.C., a Delaware limited liability company. DP IV Associates, L.P. is a Delaware limited partnership. Its sole general partner is One Palmer Square Associates IV, L.L.C., a Delaware limited liability company. Domain Associates, L.L.C. is a Delaware limited liability company.